Alteration of sex hormone levels and steroidogenic pathway by several low molecular weight phthalates and their metabolites in male zebrafish (Danio rerio) and/or human adrenal cell (H295R) line
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- 作者：Juhae Sohn<sup>asup> ; Sujin Kim<sup>asup> ; Jan Koschorreck<sup>bsup> ; Younglim Kho<sup>csup> ; Kyungho Choi<sup>asup><sup> ; sup><sup>kyungho@snu.ac.kr" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：ANOVA ; one-way analysis of variance ; 3β HSD2 ; 3β-hydroxysteroid dehydrogenase ; 17β hsd ; 17β-hydroxysteroid dehydrogenase ; 18s rrna ; 18s ribosomal rna ; BBzP ; benzylbutyl phthalate ; CHO cell ; Chinese hamster ovary cell ; cyp11a ; cholesterol side-chain cleavage enzyme gene ; cyp17 ; 17α-monooxygenase ; CYP19A ; cytochrome P450 ; DBP ; dibutyl phthalate ; DEP ; diethyl phthalate ; DiBP ; diisobutyl phthalate ; DMEM/F12 ; Dulbecco⿿s modified Eagle⿿s medium and Ham⿿s F-12 nutrient mixture ; DMP ; dimethyl phthalate
- 刊名：Journal of Hazardous Materials
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：320
- 期：Complete
- 页码：45-54
- 全文大小：2658 K
文摘
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Low molecular weight phthalates and metabolites were tested for hormone disruption.
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In fish and adrenal cell model, decreased testosterone was observed by phthalates.
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Sex hormone disruption could be explained by altered steroidogenesis.
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Hydrolytic metabolites except MiBP also showed the same disruption mechanisms.