Tetrandrine protects against oxygen-glucose-serum deprivation/reoxygenation-induced injury via PI3K/AKT/NF-κB signaling pathway in rat spinal cord astrocytes
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- 作者：Gang Bao<sup> ; sup><sup>baogang1973@aliyun.comsup><sup> ; sup><sup>gangbao321@yeah.netsup> ; Chuankun Li ; Lei Qi ; Ning Wang ; Baixiang He
- 关键词：TET ; tetrandrine ; OGSD/R ; oxygen-glucose-serum deprivation/reoxygenation ; DMEM/F12 ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium/Ham&rsquo ; s F-12 medium ; FBS ; fetal bovine serum ; TNF-α ; tumor necrosis factor-α ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; ROS ; reactive oxygen species ; MDA ; malondialdehyde ; SOD ; superoxide dismutase ; NF-κB ; nuclear factor-κB ; SCI ; spinal cord injury ; SD ; Sprague-Dawley ; IACUC ; Institutional Animal Care and Use Committee ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluore
- 刊名：Biomedicine & Pharmacotherapy
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：925-930
- 全文大小：860 K
- 卷排序：84
文摘
TET reduced OGSD/R-induced cell viability loss and apoptosis of spinal astrocytes. TET reduced OGSD/R-induced oxidative stress in spinal astrocytes. TET reduced OGSD/R-induced inflammatory response in spinal astrocytes. TET reduced OGSD/R-induced injury via PI3 K/AKT/NF-κB pathway in spinal astrocytes.