GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway
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- 作者：Hidekazu Ishida1 ; 2 ; 4 ; Rie Saba1 ; 2 ; Ioannis Kokkinopoulos1 ; 2 ; Masakazu Hashimoto7 ; Osamu Yamaguchi5 ; Sonja Nowotschin8 ; Manabu Shiraishi2 ; Prashant Ruchaya2 ; 9 ; Duncan Miller3 ; Stephen Harmer3 ; Ariel Poliandri1 ; Shigetoyo Kogaki4 ; Yasushi Sakata5 ; Leo Dunkel1 ; Andrew Tinker3 ; Anna-Katerina Hadjantonakis8 ; Yoshiki Sawa6 ; Hiroshi Sasaki7 ; Keiichi Ozono4 ; Ken Suzuki2 ; Kenta Yashiro1 ; 2 ; drkyashiro@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 July 2016
- 年：2016
- 卷：16
- 期：4
- 页码：1026-1038
- 全文大小：4991 K
文摘
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Gfra2 is specific for cardiac progenitors (CPs) among mesodermal cells
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GFRA2 enables isolation of multipotent or unipotent CPs in mouse and human
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Gfra2 and the related molecule Gfra1 play a vital role in heart development
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The GFRA1/2 signal in heart development is independent of established ligands