Interleukin-6 Gene Polymorphism in Febrile Seizures

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• 作者：Banu Guzel Nur ; MD^a ; Zelal Kahramaner ; MD^b ; Ozgur Duman ; MD^c ; Nihal Olgac Dundar ; MD^d ; Nilgun Sallakcı ; MSc^e ; Ugur Yavuzer ; MD ; PhD^f ; Senay Haspolat ; MD^c ; ^{shaspolat@akdeniz.edu.tr}
• 刊名：Pediatric Neurology
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：46
• 期：1
• 页码：36-38
• 全文大小：113 K

文摘

Febrile seizures comprise a common type of pediatric convulsion. Inflammation and genetics may be involved in their pathogenesis. Regarding the role of cytokines (especially interleukin-6) in febrile responses, we performed a case control study of interleukin-6 gene (?74,??72, and??97) single-nucleotide polymorphisms to learn if correlations existed between these particular polymorphisms and febrile seizures. We isolated the genomic DNA of 92 children with febrile seizures and 98?healthy control subjects. We genotyped individuals for their polymorphisms, using polymerase chain reaction-restriction fragment length polymorphism. In our study, the frequencies of??74 G alleles and of the??74 and??72 GG genotypes were observed to be significantly higher in patients than in control subjects. The??74 GG genotype frequency was significantly higher in children with a family history of febrile seizures.