Asymmetric total synthesis of (S)-isocorydine

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• 作者：Mei Zhong^a ; ^b ; Yunbin Jiang^c ; Yali Chen^d ; Qian Yan^a ; ^b ; Junxi Liu^a ; ^{liujx@licp.cas.cn" class="auth_mail" title="E-mail the corresponding author} ; Duolong Di^a
• 刊名：Tetrahedron: Asymmetry
• 出版年：2015
• 出版时间：1 November 2015
• 年：2015
• 卷：26
• 期：20
• 页码：1145-1149
• 全文大小：426 K

文摘

The asymmetric total synthesis of (S)-isocorydine, a potential drug for the cure of hepatocellular carcinoma, is described. Asymmetric transfer hydrogenation of 3,4-dihydroisoquinoline using a chiral Ru(II) catalyst was applied to the synthesis of isocorydine as the key step, in which the ee value achieved is up to 99%. The overall yield is 9.4% after 12 synthetic procedures.