Effects of peripheral and central administration of GHRH on feeding in aging LOU rats

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• 作者：Veyrat-Durebex ; Christelle ; Gaudreau ; Pierrette ; Boghossian ; St&eacute ; phane ; Alliot ; Josette
• 关键词：Growth hormone-releasing hormone ; Protein intake ; Lipid intake ; Feeding behavior ; Aging ; LOU/C/jall rats
• 刊名：Peptides
• 出版年：2001
• 出版时间：December, 2001
• 年：2001
• 卷：22
• 期：1
• 页码：2119-2126
• 全文大小：146 K

文摘

In aging LOU rats, a decreased protein intake is restored by GH administration. To study the contribution of GHRH to macronutrient selection, hGHRH NH₂ was administered sc. (1 mg/kg B.W./day/14 days) or icv. (4 and 40 pmol/rat) to 11-, 19-, 24- and 28-month-old rats. Sc. administration induced a decreased food and lipid intakes from 24 months of age and a transient stimulation of protein intake in 19-month-old and older low protein eaters (<10 % protein/total intake). Icv. administration induced decreased food and lipid intakes in all age groups. These results suggest that GHRH may regulate feeding through pituitary and/or hypothalamic GHRH receptor mechanisms.