HELB Is a Feedback Inhibitor of DNA End Resection
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- 作者：Já ; n Tká ; č1 ; 2 ; 9 ; Guotai Xu3 ; 9 ; Hemanta Adhikary4 ; 5 ; Jordan T.F. Young1 ; 2 ; David Gallo6 ; Cristina Escribano-Dí ; az1 ; Jana Krietsch4 ; 5 ; Alexandre Orthwein1 ; Meagan Munro1 ; Wendy Sol3 ; Abdallah Al-Hakim1 ; Zhen-Yuan Lin1 ; Jos Jonkers7 ; Piet Borst3 ; Grant W. Brown6 ; Anne-Claude Gingras1 ; 2 ; Sven Rottenberg3 ; 8 ; Jean-Yves Masson4 ; 5 ; Daniel Durocher1 ; 2 ; durocher@lunenfeld.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：61
- 期：3
- 页码：405-418
- 全文大小：2892 K
文摘
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HELB is recruited to resected DSB ends via an interaction with RPA
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HELB uses its 5′-3′ translocase activity to inhibit DNA end resection
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Nuclear export of HELB participates in the activation of resection in S phase
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HELB loss leads to PARPi resistance in BRCA1-deficient tumor cells