Boric acid complexes with thiamine (vitamin B1) and pyridoxine (vitamin B6)

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• 作者：Dursun Ali Kö ; se^a ; ^{dalikose@hitit.edu.tr" class="auth_mail} ; Birgü ; l Zumreoglu-Karan^b ; Onur Sahin^c ; Orhan Bü ; yü ; kgü ; ngö ; r^d
• 关键词：Boric acid ; Boron chelate ; Borate ester ; Thiamine ; Pyridoxine ; Crystal structure
• 刊名：Inorganica Chimica Acta
• 出版年：24 March, 2014
• 年：2014
• 卷：413
• 期：Complete
• 页码：77-83
• 全文大小：1797 K

文摘

Complexation of boric acid with vitamins B1 (thiamine) and B6 (pyridoxine) was investigated. The products were isolated from aqueous solutions and characterized by elemental analysis, FT-IR, ¹³C MAS NMR and thermal methods. The results of chemical and spectral analyses suggested that the reaction between thiaminechloride hydrochloride and H₃BO₃ in water yielded a salt-like productwith no direct bonding of the thiamine cation to boron while mono- and bis-chelate complexes were obtained with pyridoxine. The bis-chelate pyridoxine complex containing two equivalent pyridoxine ligands was obtained in crystal form. X-ray crystallography verified that complexation with boric acid occurs through the deprotonated phenolic and deprotonated adjacent alcoholic oxygen atoms forming six membered chelate rings. The negative charge on tetrahedral boron is balanced by the sodium ion. The crystal structure contains discernible tunnels parallel to the [0 1 0] direction constructed by hydrogen bonded complex molecules.