Phagocytes Get Close to Their Enemies

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• 作者：Michael L. Dustin¹ ; ^{michael.dustin@kennedy.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Simon J. Davis² ; ^{simon.davis@imm.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Developmental Cell
• 出版年：2016
• 出版时间：25 January 2016
• 年：2016
• 卷：36
• 期：2
• 页码：131-132
• 全文大小：487 K

文摘

Phagocytosis is key for many organismal functions. In a recent issue of Cell, Freeman et al. (2016) demonstrate a feed-forward signaling mechanism wherein F-actin and integrin receptors drive contact formation between phagocytes and antibody-coated solid particles, signaling their engulfment. This mechanism translates nanoscale proximity effects into wider self-propagating signals.