Peroxiredoxin 6 suppresses Muc5ac overproduction in LPS-induced airway inflammation through H₂O₂-EGFR-MAPK signaling pathway

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• 作者：Dong Yang^b ; Meiling Jin^b ; Chunxue Bai^b ; Jian Zhou^b ; ^{zhou.jian@fudan.edu.cn} ; Yao Shen^a ; ^{shen.yao@zs-hospital.sh.cn}
• 关键词：Peroxiredoxin 6 ; Muc5ac ; Epithelial growth factor receptor ; Airway inflammation ; Mitogen-activated protein kinase
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：236
• 期：Complete
• 页码：84-90
• 全文大小：1644 K
• 卷排序：236

文摘

Excessive mucin production are the common mechanism and characteristics of chronic obstructive pulmonary disease (COPD) and bronchial asthma. We demonstrate that Peroxiredoxin 6 (Prdx6) plays important roles in the development of mucin overproduction after LPS exposure. Treatment with Prdx6 may provide a new therapy against airway inflammation in the future.