Disassembly of the Dying: Mechanisms and Functions

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• 作者：Georgia K. Atkin-Smith¹ ; Ivan K.H. Poon¹ ; ^{i.poon@latrobe.edu.au}
• 关键词：apoptosis ; apoptotic bodies ; cell clearance
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：151-162
• 全文大小：2282 K
• 卷排序：27

文摘

The disassembly of an apoptotic cell into subcellular fragments, termed apoptotic bodies (ApoBDs), is a hallmark of apoptosis. Although the generation of ApoBDs is generally understood as being stochastic, it is becoming increasingly clear that ApoBD formation is a highly regulated process involving distinct morphological steps and molecular factors. Functionally, ApoBDs could facilitate the efficient clearance of apoptotic material by surrounding phagocytes as well as mediate the transfer of biomolecules including microRNAs and proteins between cells to aid in intercellular communications. Therefore, the formation of ApoBDs is an important process downstream from apoptotic cell death. We discuss here the mechanisms and functions of apoptotic cell disassembly.