Factors affecting interactions between sulphonate-terminated dendrimers and proteins: A three case study

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• 作者：Estefaní ; a Gonzá ; lez-Garcí ; a^a ; Marek Maly^b ; Francisco Javier de la Mata^c ; Rafael Gó ; mez^c ; Marí ; a Luisa Marina^a ; Marí ; a Concepció ; n Garcí ; a^a ; ^{concepcion.garcia@uah.es}
• 关键词：Sulphonate-terminated carbosilane dendrimers ; Protein-dendrimer interaction ; Fluorescence ; Quenching ; Computer modeling ; Molecular dynamics
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：196-205
• 全文大小：2218 K
• 卷排序：149

文摘

Sulphonate-terminated carbosilane dendrimers interact with proteins. Interactions greatly depend on the protein itself. High dendrimer generations and concentrations and acidic pHs favor interactions. Computer molecular modeling endorses experimental results.