We analyzed electroclinical data from 78 patients (50 males; 3-54 years) operated for intractable epilepsy due to a DNT. We compared EZ extent, defined by stereo-electroencephalography (n = 33), with the tumor and FCD areas, in each DNT subtype.
Non-specific forms (68 % ) and temporal location were predominant (73 % ). The main characteristics consisted of late childhood epilepsy onset (median 12 years), drug-resistant partial seizures and EEG abnormalities concordant with tumor location. In all DNT subtypes, intrinsic epileptogenicity was demonstrated by intralesional recordings (n = 30), displaying a depressed background activity interrupted by rapid spikes or polyspikes. EZ co-localized with the tumor in all simple and complex DNTs, but in only 1/3 of non-specific DNTs. The main discordance between the EZ and tumor extent was found in temporal non-specific DNTs associated with extensive FCD.
These results are helpful when planning surgery for DNTs.
Intrinsic epileptogenicity characterizes all DNTs; however, the EZ differs according to histologic subtypes and is particularly widespread in non-specific temporal forms.