Long-term Follow-up After Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis

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• 作者：Pablo Salinas^a ; ^{salinas.pablo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Raú ; l Moreno^a ; Luis Calvo^a ; Á ; ngel Sá ; nchez-Recalde^a ; Santiago Jimé ; nez-Valero^a ; Guillermo Galeote^a ; Teresa Ló ; pez-Ferná ; ndez^a ; Ulises Ramí ; rez^b ; Luis Riera^c ; Ignacio Plaza^d ; Isidro Moreno^e ; José ; Marí ; a Mesa^b ; José ; Luis Ló ; pez-Sendó ; n^a
• 关键词：Transcatheter aortic valve implantation ; Transcatheter aortic valve replacement ; Aortic stenosis ; Valvular heart disease ; Valve Academic Research Consortium definitions
• 刊名：Revista Española de Cardiología (English Edition)
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：69
• 期：1
• 页码：37-44
• 全文大小：328 K

文摘

Transcatheter aortic valve implantation is used as an alternative to surgical valve replacement in patients with severe aortic stenosis who are considered high-surgical-risk or inoperable. Two of the main areas of uncertainty in this field are valve durability and long-term survival.

Methods

This prospective single-center registry study from a tertiary hospital included all consecutive patients who underwent percutaneous aortic valve implantation between 2008 and 2012. Clinical follow-up lasted a minimum of 2.5 years and a maximum of 6.5 years. Valve Academic Research Consortium-2 definitions were used.

Results

Seventy-nine patients were included, with an immediate success rate of 94.9%. The median survival was 47.6 months (95% confidence intervals, 37.4-57.9 months), ie, 4 years. One quarter of deaths occurred in the first month, and most were of cardiovascular cause. After the first month, most deaths were due to noncardiovascular causes. The mean values of valve gradients did not increase during follow-up. The cumulative rate of prosthetic valve dysfunction was 15.3%, with no cases of repeat valve replacement.

Conclusions

Half of the patients with aortic stenosis who underwent transcatheter aortic valve implantation were alive 4 years after the procedure. There was a 15.3% prosthetic valve dysfunction rate in cumulative follow-up, with no cases of repeat valve replacement.