Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias
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- 作者：Tanuja Bordia1 ; Xiomara A. Perez1 ; Jaime E. Heiss ; Danhui Zhang ; Maryka Quik ; maryka.quik@sri.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAV ; adeno-associated virus ; ACh ; acetylcholine ; AIMs ; abnormal involuntary movements ; ANOVA ; analysis of variance ; LIDs ; L-dopa-induced dyskinesias ; ChAT ; choline acetyltransferase ; ChR2 ; channel rhodopsin 2 ; DAT ; dopamine transporter ; ERK ; extracellular signal regulated kinase1/2 ; mAChR ; muscarinic acetylcholine receptor ; nAChR ; nicotinic acetylcholine receptor ; 6-OHDA ; 6-hydroxydopamine
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：47-58
- 全文大小：1788 K
文摘
Short pulse stimulation of cholinergic interneurons enhanced dyskinesias.
Longer pulse stimulation of cholinergic interneurons reduced dyskinesias.
Cholinergic neuron stimulation does not affect 6-OHDA-induced motor impairment.
Striatal cholinergic interneurons play a critical role in dyskinesias.