The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer

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• 作者：Katsumi Iizuka ^{kiizuka@gifu-u.ac.jp}
• 关键词：ChREBP ; Tumorigenesis ; Steatosis ; Dyslipidemia ; Diabetes mellitus
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：474-485
• 全文大小：1815 K
• 卷排序：1863

文摘

Carbohydrate-response element-binding protein (ChREBP) is a transcription factor. ChREBP has roles in regulating glucose/lipid metabolism at the transcription level. ChREBP contributes to fatty liver, glucose intolerance, dyslipidemia, and cancer. Some drugs may modulate ChREBP activity, thereby improving hyperlipidemia/diabetes. ChREBP may be a link between development of metabolic diseases and some cancers.