Metabolic, enzymatic and gene changes are involved in glucose dysmetabolism after TBI.
Activation of glycolysis in mild TBI occurs on recovery of mitochondrial functions.
Activation of glycolysis in severe TBI occurs during mitochondrial malfunctioning.
Pentosephosphate pathway changes in severe TBI are limited to NADPH supply.
Metabolic and gene mechanisms of glucose dysregulation depend on TBI severity.