Copper at synapse: Release, binding and modulation of neurotransmission
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- 作者：Nadia D'Ambrosia ; Luisa Rossib ; luisa.rossi@uniroma2.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Copper ; Synapse ; Neurotransmission ; Neurodegeneration ; ATP7A ; NMDA
- 刊名：Neurochemistry International
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：90
- 期：Complete
- 页码：36-45
- 全文大小：937 K
文摘
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Copper is released in the synaptic cleft upon depolarization.
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Copper pump ATP7A plays a pivotal role in the release of copper at synapses.
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Copper modulates neurotransmitter receptors and synaptic vesicles trafficking.
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APP and PrP may act as copper buffer proteins at synapses.
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Copper dysmetabolism may be involved in neurodegenerative diseases.