Continuous corticosterone delivery via the drinking water or pellet implantation: A comparative study in mice

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• 作者：Sylvia J. Gasparini^a ; ^{sylvia.gasparini@sydney.edu.au} ; Marie-Christin Weber^a ; ^b ; Holger Henneicke^a ; ^c ; Sarah Kim^a ; Hong Zhou^a ; Markus J. Seibel^a ; ^d ; ^{markus.seibel@sydney.edu.au}
• 关键词：Hypercortisolism ; Corticosterone delivery ; Glucocorticoid-induced dysmetabolism ; Insulin-resistance ; Sarcopenia ; Osteoporosis
• 刊名：Steroids
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：116
• 期：Complete
• 页码：76-82
• 全文大小：1533 K
• 卷排序：116

文摘

Delivery of corticosterone via the drinking water is inexpensive and adjustable. It is safe and non-invasive and thus avoids operative stress. It closely mimics the kinetics of clinical glucocorticoid (GC) therapy. It reproduces the changes in fat, bone and muscle seen with GC therapy in humans. It is advantageous over the use of slow-release pellets.