In vivo imaging reveals impaired connectivity across cortical and subcortical networks in a mouse model of DYT1 dystonia
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- 作者：Jesse C. DeSimonea ; Marcelo Febob ; Priyank Shuklaa ; Edward Oforia ; Luis M. Colon-Perezb ; Yuqing Lic ; David E. Vaillancourta ; c ; d ; vcourt@ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DYT1 (TOR1A) ; human torsinA gene ; Dyt1 (Tor1a) ; mouse torsinA gene ; FAT ; free-water corrected fractional anisotropy ; FW ; free-water ; ICA ; independent component analysis ; KI ; knock-in mouse ; KO ; knock-out mouse ; WT ; wild-type mouse
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：35-45
- 全文大小：1547 K
文摘
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Dyt1 KI mice elicit increased connectivity in the sensory cortex and basal ganglia.
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Dyt1 KI mice show decreased connectivity in motor and cerebellar cortices.
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Functional connectivity renders high area under the curve and genotype prediction.
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Dyt1 KI mice have increased striatal and cerebellar free-water.
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Striatal and cerebellar free-water correlates with functional connectivity.