TGF-β regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling
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- 作者：Seung-il Choia ; Jun-Yup Jina ; Yong-Sun Maenga ; Tae-im Kima ; b ; Eung Kweon Kima ; b ; eungkkim@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：microRNA ; TGF-β ; TGFBI ; TGFBIp ; Granular corneal dystrophy type 2 ; Corneal fibroblasts
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 March 2016
- 年：2016
- 卷：472
- 期：1
- 页码：150-155
- 全文大小：974 K
文摘
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TGFBIp is regulated by miR-9, miRNA-21, and miR-181a in corneal fibroblasts.
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TGF-β1 induces miRNA-21, miR-181a, and TGFBIp in corneal fibroblasts.
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20">TGFBIp is positively regulated by TGF-β1 and negatively by miRNA-21 and miR-181a.
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25">These miRNAs represent potential therapeutic targets for corneal dystrophy.