4-Phenylbutyric acid reduces mutant-TGFBIp levels and ER stress through activation of ERAD pathway in corneal fibroblasts of granular corneal dystrophy type 2
详细信息 查看全文
- 作者：Seung-il Choia ; Eunhee Leea ; Jang Bin Jeonga ; Begum Akuzuma ; Yong-Sun Maenga ; Tae-im Kima ; b ; Eung Kweon Kima ; b ; eungkkim@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER stress ; UPR ; ERAD ; 4-Phenylbutyric acid ; TGFBIp ; GCD2 ; Corneal fibroblasts
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：841-846
- 全文大小：1706 K
文摘
- •
ER stress is associated with GCD2 pathogenesis.
- •
4-PBA reduce ER stress and TGFBIp.
- •
20">TGFBIp is degraded by ERAD.
- •
25">4-PBA activate ERAD.