Decreased cerebral perfusion in Duchenne muscular dystrophy patients

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• 作者：Nathalie Doorenweerd^a ; ^b ; ^c ; ^{N.Doorenweerd@lumc.nl} ; Eve M. Dumas^c ; ¹ ; Eidrees Ghariq^a ; ^b ; Sophie Schmid^a ; ^b ; Chiara S.M. Straathof^c ; Arno A.W. Roest^c ; Beatrijs H. Wokke^c ; Erik W. van Zwet^d ; Andrew G. Webb^a ; Jos G.M. Hendriksen^d ; ^e ; Mark A. van Buchem^a ; Jan J.G.M. Verschuuren^c ; Iris Asllani^f ; Erik H. Niks^c ; Matthias J.P. van Osch^a ; ^b ; Hermien E. Kan^a ; ^b
• 关键词：Brain ; CBF ; Duchenne muscular dystrophy ; Dystrophin ; Imaging
• 刊名：Neuromuscular Disorders
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：29-37
• 全文大小：2220 K
• 卷排序：27

文摘

We performed the first cerebral perfusion MRI in DMD and age-matched control boys. Globally reduced perfusion was found in DMD by on average 17%. Reduced cerebral perfusion was independent of the reduced grey matter volume.