DNAzymes Dz13 target the c-jun possess antiviral activity against influenza A viruses

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• 作者：Zhaopei Zhang^a ; ¹ ; Shouping Zhang^a ; ^b ; ^c ; ¹ ; Sanhu Wang^a ; ^{wangsanhu@hist.edu.cn}
• 关键词：Influenza A virus ; Dz13 ; C-jun ; Antiviral
• 刊名：Microbial Pathogenesis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：155-161
• 全文大小：1184 K
• 卷排序：103

文摘

DNAzymes Dz13 has no toxic on cells and mice model. Dz13 reduced IAVs viral propagation. Dz13 could improve overall survival of the H1N1-infected animals. Dz13 down-regulation of virus-induced inflammation and T cells proliferation.