3-Deazaneplanocin A suppresses aggressive phenotype-related gene expression in an oral squamous cell carcinoma cell line
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- 作者：Mitsutoki Hattaa ; hatta@college.fdcnet.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kaori Naganumab ; Kenichi Katoa ; Jun Yamazakia
- 关键词：3-Deazaneplanocin A ; Oral squamous cell carcinoma ; Epithelial&ndash ; mesenchymal transition ; Polycomb group protein ; Histone modifications
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：269-273
- 全文大小：705 K
文摘
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DZNep reduced PcG proteins and associated histone modifications in OSCC cells.
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DZNep enhanced cell–cell adhesion indicative of epithelial phenotype in OSCC cells.
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DZNep suppressed the aggressive phenotype-related gene expression in OSCC cells.
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DZNep activated the gene expression of epithelial markers in OSCC cells.