Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models
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- 作者：Bá ; lint Scheicha ; b ; g ; scheich.balint@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Balá ; zs Gasznerd ; g ; balazs.b.gaszner@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Viktó ; ria Kormosa ; b ; g ; viktoria.kormos@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kristó ; f Lá ; szló ; e ; g ; kristof.laszlo@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Csaba Á ; dorif ; csaba.adori@ki.se" class="auth_mail" title="E-mail the corresponding author ; É ; va Borbé ; lya ; b ; g ; eva.borbely@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Zsó ; fia Hajnaa ; b ; g ; zsofia.hajna@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Valé ; ria Té ; kusa ; b ; g ; valeria.tekus@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Kata Bö ; lcskeia ; b ; g ; kata.bolcskei@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Istvá ; n Á ; brahá ; mb ; e ; g ; istvan.abraham@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Erika Pinté ; ra ; b ; c ; g ; erika.pinter@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Já ; nos Szolcsá ; nyia ; b ; c ; g ; janos.szolcsanyi@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author ; Zsuzsanna Helyesa ; b ; c ; g ; h ; zsuzsanna.helyes@aok.pte.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Anxiety ; Neuropeptides ; Somatostatin ; sst4 receptor ; Fos immunohistochemistry
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：204-215
- 全文大小：3279 K
文摘
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Somatostatin receptor subtype 4 gene-deleted mice (Sstr4−/−) show increased anxiety.
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Sstr4−/− mice show increased depression-like behavior in the FST.
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The somatostatin receptor subtype 4 agonist J-2156 exerts anxiolytic effect.
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J-2156 has anidepressant-like effect in the TST and increases the Fos response.
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Somatostatin receptor subtype 4 is highly expressed in the amygdala.