文摘
Thirteen 2’-hydroxy methoxylated chalcones were synthesized. Compounds 1, 3, 4, 7 and 8 showed higher potency than flavokawin B towards T. brucei. A panel of in vitro early toxicological properties was evaluated. The formulation of compound 4 with cyclodextrins increased the oral bioavailability by 7.5 fold.