Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice
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- 作者：Anabel Garcí ; a-Herediaa ; Marta Riera-Borrulla ; Isabel Fort-Gallifaa ; b ; Fedra Luciano-Mateoa ; Noemí ; Cabré ; a ; Anna Herná ; ndez-Aguileraa ; Jorge Jovena ; Jordi Campsa ; jcamps@grupsagessa.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antioxidants ; Hepatotoxicity ; Inflammation ; Metformin ; NAFLD ; Paraoxonase ; Steatosis
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：249
- 期：Complete
- 页码：56-63
- 全文大小：2784 K
文摘
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Studies have reported toxic effects of metformin in patients with liver disease.
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PON1 is an antioxidant enzyme synthesized mainly by the liver.
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We found that metformin administration increases steatosis and inflammation in PON1-deficient mice.
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PON1 deficiency is associated with toxic effects of metformin in the liver.