Donor Immunization Against Human Leukocyte Class II Antigens is a Risk Factor for Graft-versus-Host Disease
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- 作者：Florent Delbos1 ; Walid Barhoumi2 ; Ludovic Cabanne2 ; Florence Beckerich2 ; Christine Robin2 ; Rabah Redjoul2 ; Safae Astati2 ; André ; a Toma2 ; Cé ; cile Pautas2 ; Hé ; lè ; ne Ansart-Pirenne1 ; Catherine Cordonnier2 ; Philippe Bierling1 ; 3 ; Sé ; bastien Maury2 ; 3 ; 4 ; sebastien.maury@hmn.aphp.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-HLA antibodies ; Graft-versus-host disease ; Risk factor analysis
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：22
- 期：2
- 页码：292-299
- 全文大小：671 K
文摘
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The detection of anti-HLA antibodies using the Luminex assay is a frequent event in allogeneic hematopoietic stem cell transplantation donors.
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We analyzed the impact of anti-HLA antibodies detected in voluntary unrelated donors on the occurrence of graft-versus-host disease (GVHD).
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The cumulative incidence of chronic GVHD was significantly enhanced in recipients of grafts from anti-HLA–immunized donors.