Lipid and mechano-gated 2P domain K⁺ channels

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• 作者：Patel ; Amanda J. ; Lazdunski ; Michel ; Honor&eacute ; Eric
• 关键词：Arachidonic acid ; lysophosphatidylcholine ; stretch ; mechano-transduction ; bilayer ; S channel ; presynaptic facilitation ; Cell biology
• 刊名：Current Opinion in Cell Biology
• 出版年：2001
• 出版时间：August 1, 2001
• 年：2001
• 卷：13
• 期：4
• 页码：422-428
• 全文大小：621 K

文摘

The two pore domain K⁺ channels TREK and TRAAK are opened by membrane stretch. The activating mechanical force comes from the bilayer membrane and is independent of the cytoskeleton. Emerging work shows that mechano-gated TREK and TRAAK are opened by various lipids, including long chain polyunsaturated anionic fatty acids and neutral cone-shaped lysophospholipids. TREK-1 shares the properties of the Aplysia neuronal S channel, a presynaptic background K⁺ channel involved in behavioral sensitization, a simple form of learning.