Isolation of novel stilbenoids from the roots of Cyrtopodium paniculatum (Orchidaceae)

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• 作者：Florence Auberon^a ; ^{florence.auberon@gmail.com} ; Opeyemi Joshua Olatunji^a ; Diamondra Raminoson^a ; Christian D. Muller^b ; Beatriz Soengas^c ; Fr&eacute ; d&eacute ; ric Bont&eacute ; ^c ; Annelise Lobstein^a
• 关键词：Cyrtopodium paniculatum ; Orchidaceae ; Stilbenoids ; Phenanthrenes ; Phenanthrene dimers ; Human glioblastoma
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：99-105
• 全文大小：657 K
• 卷排序：116

文摘

Four new stilbenoids, named cyrtopodinone (1), cyrtopodinol (2), and coeludols A and B (3–4) were isolated from the roots of Cyrtopodium paniculatum, together with 21 known stilbenoids derivatives (5–25). Their structures were elucidated by comprehensive spectroscopic analysis including extensive 1D and 2D-NMR techniques. The cytotoxic activities of the isolated compounds were tested on human glioblastoma U-87MG cell line with fluorescence-based image cytometry. Only four compounds (18, 19, 22 and 25) displayed moderate cytotoxicity with IC50 values of 45.2, 39.9, 58.2 and 48.0 μM, respectively.