Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats
详细信息 查看全文
- 作者：Juciane Lauren Cavalcanti Cardosoa ; Vera Lucia Lanchotea ; Maria Paula Marques Pereiraa ; Jorge Manuel Vieira Capelab ; Natá ; lia Valadares de Moraesc ; José ; Salvador Leperac ; salvadorlepera@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ethanol fuel ; Inhalation ; Pharmacokinetics ; CYP3A ; CYP2C ; CYP2D
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：84
- 期：Complete
- 页码：99-105
- 全文大小：528 K
文摘
- •
The effect of ethanol fuel inhalation on cytochrome P450 activity was investigated.
- •
Verapamil, ibuprofen and fluoxetine were used as probes of CYP3A, 2C and 2D.
- •
Inhalation of ethanol fuel at 2 times the TLV-STEL induced CYP3A and CYP2C, but inhibited CYP2D in rats.