Work-exacerbated asthma and occupational asthma: Do?they really differ?

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• 作者：Catherine Lemiè ; re ; MD ; MSc^a ; ^{catherine.lemiere@umontreal.ca} ; Louis-Phillippe Boulet ; MD^b ; Simone Chaboillez ; RT^a ; Am&eacute ; lie Forget ; MSc^a ; Samah Chiry ; MD ; MSc^a ; H&eacute ; lè ; ne Villeneuve ; RN^b ; Philippe Prince ; MSc^b ; Karim Maghni ; DSc ; PhD^a ; Wendy A. Kennedy ; PhD^a ; Lucie Blais ; PhD^a ; ^c
• 关键词：Cost ; health care use ; occupational asthma ; sputum eosinophils ; work-exacerbated asthma
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：131
• 期：3
• 页码：704-710.e3
• 全文大小：147 K

文摘

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Background

Although work-exacerbated asthma (WEA) is a prevalent condition likely to have an important societal burden, there are limited data on this condition.

Objectives

The aims of this study were (1) to compare the clinical, functional, and inflammatory characteristics of workers with WEA and occupational asthma (OA) and (2) compare health care use and related costs between workers with WEA and OA, as well as between workers with work-related asthma (WRA; ie, WEA plus OA) and those with non-work-related asthma (NWRA) in a prospective study.

Methods

We performed a prospective observational study of workers with and without WRA with a 2-year follow-up. The diagnosis of OA and WEA was based on the positivity and negativity of results on specific inhalation challenges, respectively.

Results

One hundred fifty-four subjects were enrolled: 53 with WEA, 68 with OA, and 33 control asthmatic subjects (NWRA). WEA was associated with more frequent prescriptions of inhaled corticosteroids (odds ratio [OR], 4.4; 95 % CI, 1.4-13.6; P?= .009), a noneosinophilic phenotype (OR, 0.3; 95 % CI, 0.1-0.9; P?= .04), a trend toward a lower FEV₁ (OR, 0.9; 95 % CI, 0.9-1.0; P?= .06), and a higher proportion of smokers (OR, 2.5; 95 % CI, 0.96-9.7; P?= .06) than the diagnosis of OA. The health care use of WRA and related costs were 10-fold higher than those of NWRA.

Conclusion

Workers with WEA appeared to have features of greater asthma severity than workers with OA. In contrast with OA, WEA was associated with a noneosinophilic phenotype. Both OA and WEA were associated with greater health care use and 10-fold higher direct costs than NWRA.