Discovery of host-targeted covalent inhibitors of dengue virus

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• 作者：M&eacute ; lissanne de Wispelaere^a ; Margot Carocci^a ; Yanke Liang^b ; ^c ; Qingsong Liu^b ; ^c ; Eileen Sun^d ; Michael L. Vetter^a ; Jinhua Wang^b ; ^c ; Nathanael S. Gray^b ; ^c ; Priscilla L. Yang^a ; ^{priscilla_yang@hms.harvard.edu}
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：171-179
• 全文大小：1945 K
• 卷排序：139

文摘

Targeting the host cysteinome leads to the discovery of broad-spectrum antivirals. The covalent inhibitor QL-XII-47 potently inhibits dengue virus. QL-XII-47 and related compounds block viral protein expression. QL-XII-47 exhibits broad-spectrum antiviral activity.