0437 : Voluntary exercise training is beneficial in non-ischemic heart failure

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• 作者：Robin Deloux¹ ; ^{robin.deloux@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mathias Mericskay¹ ; Nathalie Mougenot¹ ; R&eacute ; mi Thomasson² ; Phillipe Noirez² ; Zhenlin Li¹ ; Arnaud Ferry¹ ; Onnik Agbulut¹
• 刊名：Archives of Cardiovascular Diseases Supplements
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：8
• 期：3
• 页码：240
• 全文大小：50 K

文摘

Despite the well-known impact of exercise training in the prevention of cardiovascular diseases, few studies have been made to clarify the effects of exercise training in non-ischemic cardiomyopathies. In this study, we focused on the role of voluntary exercise training in a murine model of dilated cardiomyopathy (αMHC-MerCreMer:Sf/Sf) induced by cardiac-specific and tamoxifen-inductible inactivation of the Serum Response Factor.

Methods and results

r0010">Seven days after tamoxifen injection, twenty-two mice αMHC-MerCreMer:Sf/Sf mice were allocated to sham (n=8, sedentary) and treated (n=14, voluntary wheel running) groups. In addition, seven αMHCMerCreMer: Sf/Sf mice without tamoxifen treatment were used as control. Treated group underwent four weeks of voluntary exercise on wheel (run 1.65±0.25 km/d). Cardiac function, fibrosis content and energetic metabolism were then blindly assessed in all animals. In treated group, fractional shortening declined less compared to sedentary group. This correlated with a lesser degree of LV remodeling, as LV end-diastolic and end-systolic diameters increased less from baseline values in exercised group compared to sedentary animals. Exercised animals also displayed a reduced gene expression of the stress-induced atrial and brain natriuretic factors. These protective effects were accompanied by a reduction of myocardial fibrosis. Moreover, exercise induces Peroxisome proliferator-activated receptor ©coactivator 1-alpha and mitochondrial aconitase protein levels suggesting that enhancement of mitochondrial biogenesis and/or metabolism slow down the progression of dilated cardiomyopathy.

Conclusions

r0015">These results strongly support the interest of voluntary exercise training to the non-ischemic heart failure outcome with potential for its clinical use in the future.

r1005">The author hereby declares no conflict of interest