A revisited structure for nitrosoprodenafil from NMR, mass spectrometry, X-ray and hydrolysis data

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• 作者：Robert Martino^a ; Christophe Menendez^a ; St&eacute ; phane Balayssac^a ; Nathalie Martins-Froment^b ; Christian Lherbet^a ; Franç ; ois Couderc^c ; V&eacute ; ronique Gilard^a ; Myriam Malet-Martino^a ; ^{martino@chimie.ups-tlse.fr}
• 关键词：Nitrosoprodenafil ; Nitropromethisosildenafil ; NMR ; Mass spectrometry ; X-ray crystallography
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：31-49
• 全文大小：4779 K
• 卷排序：135

文摘

An already-known adulterant was isolated from an erectile dietary supplement. Its structure was re-established with NMR, MS and X-ray. As its hydrolysis gave methisosildenafil, it was named nitropromethisosildenafil. It was easily synthesized from thiomethisosildenafil and chloromethylnitroimidazole.