The pineal germinoma can share chromosomal alterations with gonadal tumors. Amplification in 1q24.2, 1q31.3 and 1q21.3 are the most important in pineal germinoma. The deletions in 11q11 is the most important in germ cell tumors. The genes PPAPDC1B and NPC2 play an important role in the tumorigenesis.