Novel hybrids β-carboline-4-thiazolidinones were synthetized.
Compounds were evaluated for their in vitro antitumor and antiviral activities.
Compounds 9c and 11d displayed potent antitumor activity in vitro.
Compound 9c induced cell death in the renal human tumor cell line 786-0.
Potent anti-HSV-1 activity was observed for derivatives 18, 19 and 22.