Synthesis and evaluation of novel hybrids β-carboline-4-thiazolidinones as potential antitumor and antiviral agents
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- 作者：Valé ; ria Aquilino Barbosaa ; Paula Baré ; aa ; Renata Sespede Maziab ; Tania Ueda-Nakamurab ; Willian Ferreira da Costaa ; Mary Ann Foglioc ; Ana Lucia T. Goes Ruizc ; Joã ; o Ernesto de Carvalhoc ; Dé ; bora Barbosa Vendramini&ndash ; Costac ; Celso Vataru Nakamurab ; Maria Helena Sarragiottoa ; mhsarragiotto@uem.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-Carboline ; 4-Thiazolidinone ; Antitumor ; Antiviral
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：1093-1104
- 全文大小：706 K
文摘
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Novel hybrids β-carboline-4-thiazolidinones were synthetized.
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Compounds were evaluated for their in vitro antitumor and antiviral activities.
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Compounds 9c and 11d displayed potent antitumor activity in vitro.
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Compound 9c induced cell death in the renal human tumor cell line 786-0.
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Potent anti-HSV-1 activity was observed for derivatives 18, 19 and 22.