Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway

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• 作者：Raguenes-Nicol ; C&eacute ; line ; Russo-Marie ; Franç ; oise ; Domage ; Gisè ; le ; Diab ; Nadia ; et. al.
• 关键词：PLA₂ ; melittin ; alminoprofen ; anti-inflammatory drugs ; cyclooxygenase
• 刊名：Biochemical Pharmacology
• 出版年：1999
• 出版时间：February 15, 1999
• 年：1999
• 卷：57
• 期：4
• 页码：433-443
• 全文大小：463 K

文摘

Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. It has anti-inflammatory properties different from the classical NSAID. Using both in vitro systems of cells in culture and in vivo models of inflammation, we report here that alminoprofen possesses both antiphospholipase A₂ (PLA₂) activity and anti-cycloxygenase (COX) activity. The PLA₂ targeted by alminoprofen is likely the secretory phospholipase A₂ (sPLA₂) while the COX targeted is the COX-2.