Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; association with systolic blood pressure in the high normal range

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• 作者：Daniel Rinnströ ; m^a ; Mikael Dellborg^b ; Ulf Thil&eacute ; n^c ; Peder Sö ; rensson^d ; Niels-Eric Nielsen^e ; Christina Christersson^f ; Bengt Johansson^a ; ^{bengt.johansson@umu.se" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CoA ; Hypertension ; Left ventricular hypertrophy ; Adult congenital heart disease
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：218
• 期：Complete
• 页码：59-64
• 全文大小：235 K

文摘

Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population.

Material and results

From the national register for congenital heart disease, 506 adult patients (≥ 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 ± 13.8 years, with an average of 26.8 ± 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01–1.04), aortic valve disease, (OR 2.17, CI 1.33–3.53), age (years) (OR 1.03, CI 1.01–1.05), diagnosis of arterial hypertension (OR 3.02, CI 1.81–5.02), and sex (female) (OR 0.41, CI 0.24–0.72) were independently associated with LVH. There was an association with LVH at SBP within the upper reference limits [130, 140] mm Hg (OR 2.23, CI 1.05–4.73) that further increased for SBP > 140 mm Hg (OR 8.02, CI 3.76–17.12).

Conclusions

LVH is common post repair of CoA and is associated with SBP even below the currently recommended target level. Lower target levels may therefore become justified in this population.

ORCID Id: 0000-0003-0976-6910