Peritoneal carcinomatosis: A malignant disease with an embryological origin?
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- 作者：Augusto Pereira
- 关键词：Peritoneal carcinomatosis ; Ovarian cancer ; Lateral plate mesoderm ; Cancer stem cells ; Genetic and epigenetic changes ; Dormant cells
- 刊名：Surgical Oncology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：24
- 期：3
- 页码：305-311
- 全文大小：604 K
文摘
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- <p id="p0010">Transcoelomic spread was described as a main route for PC dissemination.p>
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- <p id="p0015">Metaplasia of pluripotent stem cells and synchronous malignant transformation, may cause intraperitoneal field cancerization.p>
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- <p id="p0020">In PC, most serous metastases presented a common embryological origin in the lateral plate of mesoderm.p>
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- <p id="p0300">Genetic and epigenetic changes, could mark the structures derived from mesoderm, affecting their cell linage descendants.p>