Synthesis of ¦Á-alkenyl-¦Á-amino esters via addition of potassium Alkenyltrifluoroborate salts to imine in the presence of Yb(OTf)₃

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• 作者：H¨¦lio A. Stefani ; Amna N. Khan ; Fl¨¢via Manarin ; Pedro H. Vendramini ; Marcos N. Eberlin
• 关键词：Vinyltrifluoroborate ; Amino acid ; Addition reaction ; Lewis acid ; Ytterbium
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：13 November, 2013
• 年：2013
• 卷：54
• 期：46
• 页码：6204-6207
• 全文大小：2237 K

文摘

A simple protocol which led to an effective construction of ¦Á-alkenyl-¦Á-amino esters was achieved under mild conditions. This transformation proceeded by Yb-catalyzed addition of alkenyltrifluoroborates across the imine double bond. A variety of functional groups could be applicable to both partners.