Anti-inflammatory effects of interleukin-35 in acquired aplastic anemia
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- 作者：Wei Yu1 ; Meili Ge1 ; Shihong Lu ; Jun Shi ; Xingxin Li ; Jizhou Zhang ; Min Wang ; Jinbo Huang ; Yingqi Shao ; Zhendong Huang ; Jing Zhang ; Neng Nie ; Yizhou Zheng ; zheng_yizhou@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; aplastic anemia ; BM ; bone marrow ; CR ; complete response ; EBI3 ; Epstein&ndash ; Barr virus-induced protein 3 ; IFN-纬 ; interferon-纬 ; IL ; interleukin ; IST ; immunosuppressive therapy ; Non-SAA ; non-severe AA ; PB ; peripheral blood ; PBMCs ; peripheral blood mononuclear cells ; Tc ; cytotoxic T ; TGF-尾 ; transforming growth factor-尾 ; Th ; T helper ; TNF-伪 ; tumor necrosis factor-伪 ; Tregs ; regulatory T cells ; VSAA ; very severe AA
- 刊名：Cytokine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：76
- 期：2
- 页码：409-416
- 全文大小：1155 K
文摘
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Plasma IL-35 levels were decreased in AA patients compared to healthy controls.
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Decreased IL-35 was closely correlated with disease severity of AA.
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IL-35 modulated the secretion of pro- and anti-inflammatory cytokines of AA.
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IL-35 regulated the differentiation of T cell subsets of AA.