Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia

详细信息    查看全文

• 作者：J.R. Prins^a ; ^{j.r.prins@umcg.nl" class="auth_mail" title="E-mail the corresponding author} ; M.L.P. van der Hoorn^b ; R. Keijser^c ; C. Ris-Stalpers^c ; ^d ; E. van Beelen^b ; G.B. Afink^c ; F.H.J. Claas^e ; J.A.M. van der Post^d ; S.A. Scherjon^e ; ¹
• 关键词：Preeclampsia ; Immunology ; EBI3 ; HLA-G ; Pregnancy
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：77
• 期：1
• 页码：68-70
• 全文大小：438 K

文摘

The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein–Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p < 0.05) and HLA-G (p < 0.01) mRNA expression in preeclampsia (n = 7) compared to normotensive (n = 8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed.