EBNA1 antigen-specific CD8 + T cells in cerebrospinal fluid of patients with multiple sclerosis
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- 作者：Hebun Erdura ; hebun.erdur@charite.de" class="auth_mail" title="E-mail the corresponding author ; Veronika Scholza ; Mathias Streitzb ; Markus Hammerc ; Christian Meiselb ; Constanze Schö ; nemannd ; Klaus-Peter Wandingere ; f ; Berit Roschea
- 关键词：MS ; multiple sclerosis ; CSF ; cerebrospinal fluid ; CMV ; cytomegalovirus ; EBV ; Epstein Barr virus ; EBNA1 ; EBV-encoded nuclear antigen-1
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：294
- 期：Complete
- 页码：14-17
- 全文大小：357 K
文摘
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CD8 + T cells specific for one EBNA1-derived epitope (HPVGEADYFEY) were detected in blood and CSF of MS patients.
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10">Their frequency did not differ significantly in blood nor CSF in MS compared to other inflammatory neurological diseases.
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15">Frequency of HPVGEADYFEY-specific CD8 + T cells was consistently higher in CSF compared to blood regardless of diagnosis.