CRY2 and FBXL3 Cooperatively Degrade c-MYC
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- 作者：Anne-Laure Huber1 ; Stephanie J. Papp1 ; Alanna B. Chan1 ; Emma Henriksson1 ; 4 ; Sabine D. Jordan1 ; Anna Kriebs1 ; Madelena Nguyen1 ; Martina Wallace2 ; Zhizhong Li3 ; Christian M. Metallo2 ; Katja A. Lamia1 ; 5 ; klamia@scripps.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：circadian rhythm ; MYC ; CRY2 ; cryptochrome ; FBXL3 ; ubiquitin ; circadian clock
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：64
- 期：4
- 页码：774-789
- 全文大小：5957 K
文摘
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Loss of CRY2 stabilizes c-MYC and enhances cellular transformation
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CRY2 can function as a co-factor for the SCF substrate adaptor FBXL3
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c-MYC phosphorylated on threonine 58 (T58) interacts with CRY2
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SCFFBXL3+CRY2 promotes the ubiquitylation and turnover of c-MYC