Predominant role of spinal P2Y1 receptors in the development of neuropathic pain in rats
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- 作者：Paulino Barragá ; n-Iglesiasa ; b ; Jorge Baruch Pineda-Fariasa ; Mariana Bravo-Herná ; ndeza ; Claudia Cervantes-Durá ; na ; Theodore J. Priceb ; Janet Murbartiá ; na ; Vinicio Granados-Sotoa ; vgranados@prodigy.net.mx" class="auth_mail" title="E-mail the corresponding author ; vgranados@cinvestav.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADP ; Adenosine 5&prime ; - diphosphate ; ATP ; Adenosine 5&prime ; -triphosphate ; CCI ; Chronic constriction injury ; CFA ; Complete Freund׳s adjuvant ; DRG ; Dorsal root ganglia ; ERK1/2 ; Extracellular signal-regulated kinases ; MRS2500 ; (1R* ; 2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt ; p38 MAPK ; p38 mitogen-activated protein kinase ; SNI ; Spared nerve injury ; SNL ; Spinal nerve ligation ; UDP ; Uridine-5&prime ; -diph
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1636
- 期：Complete
- 页码：43-51
- 全文大小：1863 K
文摘
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CCI, SNI or SNL enhanced expression of P2Y1 receptors in DRG 1–3 days after injury.
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Intrathecal MRS2500 reduced tactile allodynia in rats 1–3 days after CCI, SNI or SNL.
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Intrathecal MRS2500 reduced injury-induced up-regulation of P2Y1 receptor expression.
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Intrathecal MRS2500 lost antiallodynic effect when injected 14 days after injury.
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Spinal P2Y1 receptors participate in the development of neuropathic pain.