NMDAR antagonists blocks depotentiation of stabilized hippocampal E-LTP and L-LTP.
Chronic post-acquisition blockade of NMDAR protects LTMs from its active decay.
Endocytosis of GluA2-containing AMPAR is one of the main signatures underlying forgetting.
Decay of the L-LTP or LTM might rely on spine shrinkage through LIMK/cofilin-mediated signalling.
Ubiquitin-proteasome system may regulate both memory destabilization and forgetting.