Comparison of the lethal effects of chemical warfare nerve agents across multiple ages
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- 作者：Linnzi K.M. Wrighta ; 1 ; Robyn B. Leea ; Nicole M. Vincellib ; Christopher E. Whalleyb ; Lucille A. Lumleya ; lucille.a.lange.civ@mail.mil" class="auth_mail" title="E-mail the corresponding author ; lucylange@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; BARDA ; Biomedical Advanced Research and Development Authority ; CWNA ; chemical warfare nerve agent(s) ; CI ; confidence interval ; GF ; cyclosarin ; ECBC ; Edgewood Chemical Biological Center ; LD50 ; median lethal dose ; PND ; postnatal day ; VR ; Russian VX ; GB ; sarin ; GD ; soman ; sc ; subcutaneous(ly) ; GA ; tabun ; USAMRICD ; US Army Medical Research Institute of Chemical Defense
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：241
- 期：Complete
- 页码：167-174
- 全文大小：1058 K
文摘
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Children may be more vulnerable than adults to chemical warfare nerve agents (CWNA).
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We estimated the 24 h LD50 for seven CWNA in rats at six times in development.
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Perinatal and adult rats were more susceptible than pubertal rats to the G-agents.
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Age-related differences were not observed in rats for the V-agents.