Multi-scale modeling of soft fibrous tissues based on proteoglycan mechanics
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- 作者：Kevin Linka ; linka@km.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Vu Ngoc Khiê ; m ; Mikhail Itskov
- 关键词：Multi-scale modeling ; Soft fibrous tissues ; Proteoglycans
- 刊名：Journal of Biomechanics
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：49
- 期：12
- 页码：2349-2357
- 全文大小：1325 K
文摘
Collagen in the form of fibers or fibrils is an essential source of strength and structural integrity in most organs of the human body. Recently, with the help of complex experimental setups, a paradigm change concerning the mechanical contribution of proteoglycans (PGs) took place. Accordingly, PG connections protect the surrounding collagen fibrils from over-stretching rather than transmitting load between them. In this paper, we describe the reported PG mechanics and incorporate it into a multi-scale model of soft fibrous tissues. To this end, a nano-to-micro model of a single collagen fiber is developed by taking the entropic-energetic transition on the collagen molecule level into account. The microscopic damage occurring inside the collagen fiber is elucidated by sliding of PGs as well as by over-stretched collagen molecules. Predictions of this two-constituent-damage model are compared to experimental data available in the literature.